Let Doctors Be Doctors –Don’t Let Engineers Determine Injuries

Let There Be Light!

The invention of the microscope has been fundamental for the understanding of tissue architecture and subcellular structures. With the advancement of higher magnification microscopes came the development of various molecular biology tools such as Förster resonance energy transfer (FRET) and in situ proximity ligation assay (in situ PLA) to monitor protein interactions. Microscopy has become a c...

Let There Be Light

Let There Be Sight

levels. This fits well with the observation that the repul-1998). It remains to be seen, however, whether these or 1133.102, 363–375. tions be in mediating guidance decisions at choice points? Another possible site for this mechanism to operate is at the ventral midline of the CNS. In vertebrates, commissural axon crossing of the ventral midline of the spinal cord is regulated by a combination ...

Let Should Not Be Generalised

From the dawn of time, all derivatives of the classic Hindley-Milner type system have supported implicit generalisation of local letbindings. Yet, as we will show, for more sophisticated type systems implicit let-generalisation imposes a disproportionate complexity burden. Moreover, it turns out that the feature is very seldom used, so we propose to eliminate it. The payoff is a substantial sim...

Let there be a channel

found that self-organizing waves of NAD(P)H can help neutrophils to destroy their targets. When the waves reach the front of the cell, the NAD(P)H donates an electron to NADPH oxidase, which passes it on to oxygen to form reactive oxygen metabolites (ROMs) that help weaken the membranes of bacterial, virus-infected and tumor cells. The team first described the existence of NAD(P)H waves in a pa...